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Sildenafil (compound UK-92,480) is a potent and selective inhibitor of cGMP-specific phosphodiesterase type-5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections.

Sildenafil was originally developed by Pfizer as a treatment for angina, or chest pain. The drug was originally developed as a treatment for angina, a chest pain associated with coronary heart disease. Angina occurs when the heart is not receiving enough blood. Sildenafil relaxes the smooth muscles in the walls of blood vessels and allows blood to flow more easily to the heart, relieving the chest pain.

In 1998, Pfizer filed a patent covering the use of sildenafil to treat erectile dysfunction. This was the first time a drug had been developed specifically to treat erectile dysfunction. The patent was later extended to cover the treatment of pulmonary arterial hypertension.

Sildenafil is available as a generic drug in the United Kingdom, United States and in other countries. The patent for Viagra expired in the UK in June 2013, allowing other drug companies to make and market their own versions of sildenafil.

Generic sildenafil is marketed under many different brand names, including:

  • Aurogra
  • Caverta
  • Eriacta
  • Intagra
  • Kamagra
  • Mintaga
  • Revatio
  • Silagra
  • Suhagra
  • Vegra
  • Viagra
  • Vigora

Sildenafil is also available as a generic drug in other countries, including:

  • Australia
  • Canada
  • France
  • Germany
  • India
  • Ireland
  • Italy
  • New Zealand
  • South Africa
  • Spain
  • Switzerland
  • United Kingdom
  • United States

Sildenafil is a prescription drug that is not available over-the-counter (OTC). In order to get a prescription for sildenafil, you must first consult with a doctor.

How does sildenafil work?

Sildenafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cGMP in the corpus cavernosum. Sildenafil relaxes the smooth muscles in the walls of blood vessels and allows blood to flow more easily to the heart, relieving the chest pain.

In 1998, Pfizer filed a patent covering the use of sildenafil to treat erectile dysfunction. This was the first time a drug had been developed specifically to treat erectile dysfunction. The patent was later extended to cover the treatment of pulmonary arterial hypertension.

What are the side effects of sildenafil?

The most common side effects of sildenafil are headache, flushing, indigestion, nasal congestion, and temporary changes in vision.

Sildenafil can cause serious side effects in some people. These include:

  • heart attack
  • stroke
  • increased blood pressure
  • sudden death
  • vision loss
  • ringing in the ears
  • seizures
  • allergic reactions
  • skin rash

If you experience any of these side effects, you should seek medical attention immediately.

How do I take sildenafil?

Sildenafil is available as tablets, film-coated tablets, and oral suspension. The tablets are available in 25 mg, 50 mg, and 100 mg doses. The film-coated tablets are available in 25 mg, 50 mg, and 100 mg doses. The oral suspension is available in 25 mg/mL and 50 mg/mL doses.

The recommended starting dose for erectile dysfunction is 50 mg, taken one hour before sexual activity. The maximum recommended dose is 100 mg. The recommended starting dose for pulmonary arterial hypertension is 40 mg, taken three times a day. The maximum recommended dose is 200 mg.

You should not take sildenafil more than once a day. If you take sildenafil more than once a day, you should take it at least four hours apart.

You should take sildenafil on an empty stomach. Sildenafil should be taken one hour before sexual activity.

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